The specific immunological purpose of conducting a pre-transplant crossmatch test, such as flow cytometry crossmatch, is to identify and prevent immediate, severe, antibody-mediated immune rejection of a transplanted organ. This test aims to detect the presence of pre-formed alloantibodies in the recipient's serum that are specifically directed against Human Leukocyte Antigens (HLA) expressed on the donor's cells. Alloantibodies are antibodies produced by an individual that recognize and react with antigens from another individual of the same species. HLA proteins are major histocompatibility complex (MHC) molecules, critical for immune recognition, found on ....
Log in to view the answer
