Name one specific long-term systemic side effect commonly associated with therapeutic doses of calcineurin inhibitors like tacrolimus.

One specific long-term systemic side effect commonly associated with therapeutic doses of calcineurin inhibitors like tacrolimus is nephrotoxicity, which means damage to the kidneys. Calcineurin inhibitors are a class of immunosuppressive drugs, with tacrolimus being a widely used example, prescribed at therapeutic doses—meaning the appropriate amounts for treatment—primarily to prevent the immune system from rejecting a transplanted organ. These drugs achieve this by inhibiting calcineurin, an enzyme crucial for the activation of T-lymphocytes, which are immune cells involved in re....