What specific data transformation is applied to ATAC-Seq signal profiles to effectively distinguish true transcription factor binding sites from background genomic noise?
The specific data transformation applied to ATAC-Seq signal profiles to distinguish true transcription factor binding sites from background noise is called Tn5 transposase bias correction. ATAC-Seq works by using an enzyme called Tn5 transposase to insert sequencing adapters into open chromatin regions. However, Tn5 has an intrinsic chemical preference for certain shor....
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Abdullah Mohammed Aljohani
“Tn5 insertion bias correction (footprinting), producing a footprinting signal where a deplection of insertions at the transcription factor binding site is flanked by enriched accessibility, distinguishing true binding sites from background genomic noise.”
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