Which cytochrome P450 enzyme is primarily responsible for the conversion of codeine to its active metabolite, morphine?

The cytochrome P450 enzyme primarily responsible for the conversion of codeine to its active metabolite, morphine, is CYP2D6. Cytochrome P450 enzymes are a superfamily of enzymes involved in the metabolism of many drugs, including opioids. Codeine itself has relatively low affinity for opioid receptors and is considered a prodrug, meaning it needs to be metabolized into a more active form to exert its ana....