Stimulant use contributes to an increased risk of arrhythmias through several mechanisms related to their effects on the cardiovascular system. Arrhythmias are irregular heartbeats that can range from mild to life-threatening. Stimulants, such as cocaine and amphetamine, primarily increase the levels of norepinephrine and dopamine in the synapse. This increase in norepinephrine leads to the activation of adrenergic receptors in the heart. Activation of beta-1 adrenergic re....
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