Identify the primary lymphatic drainage basin for a squamous cell carcinoma originating in the anterior two-thirds of the tongue.

The primary lymphatic drainage basin for a squamous cell carcinoma originating in the anterior two-thirds of the tongue is predominantly the submandibular lymph nodes, followed by the deep cervical lymph nodes. Squamous cell carcinoma is a type of cancer that begins in the squamous cells, which are flat, thin cells that form the lining of certain parts of the body, including the surface of the tongue. The anterior two-thirds of the tongue refers to the front portion of the tongue, specifically the part in front of the circumvallate papillae. The primary lymphatic drainage basin refers to the first group of lymph nodes to which lymphatic fluid, and potentially cancer cells, from a specific anatomical region will drain. For the anterior two-thirds of the tongue, lymphatic vessels first collect fluid and drain into the submandibular lymph nodes, which are located beneath the mandible (jawbone). From the submandibular nodes, the lymphatic flow then progresses to the superior deep cervical lymph nodes, particularly the jugulodigastric nodes, which are part of the chain of lymph nodes running along the internal jugular vein in the neck. Following this, drainage continues to the inferior deep cervical lymph nodes. Importantly, lymphatic drainage from the anterior two-thirds of the tongue, especially the tip and midline areas, can often be bilateral, meaning cancer cells may spread to lymph nodes on both sides of the neck, not just the side where the tumor originated.