Several factors determine the rate of hydrolysis in biodegradable polymers. First, the chemical structure of the polymer is crucial. Polymers containing hydrolyzable bonds, such as ester, amide, or anhydride linkages, are more susceptible to hydrolysis. The specific type of hydrolyzable bond and its surrounding chemical environment influence the rate of hydrolysis. Second, the hydrophilicity of the polymer affects the rate of water absorption and penetration, which is essential for hydrolysis. Hydrophilic polymers a....
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