In stochastic modeling of gene expression, which statistical distribution is used to quantify the variance of mRNA production caused by the discrete nature of promoter activation and deactivation?

In stochastic modeling of gene expression, the statistical distribution used to quantify the variance caused by promoter switching is the telegraph model, which results in a negative binomial distribution for the steady-state mRNA copy numbers. Gene expression is inherently stochastic, meaning it is governed by random fluctuations due to the low number of molecules involved in the process. The telegraph model describes a p....