Telomere shortening is a natural process that occurs as cells divide over time. However, when telomeres become critically short, they can no longer effectively protect the chromosome from damage and loss, leading to cellular senescence, apoptosis, or impaired cell function.
Cellular senescence is a state of permanent cell cycle arrest that occurs in response to a variety of stresses, including telomere shortening. Senescent cells can accumulate in tissues with age, leading to tissue dysfunction and inflammation, which contributes to age-rel....
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